Clinical Trials

Colorado Springs Neurological Associates is one of the largest and longest-standing neuroscience medical practices in southern Colorado.  Our aim is to deliver the highest standard of neurological care – the same level of care we would want for ourselves or our loved ones.  The Center has a dedicated clinical research institute with experienced principal investigators and a full-time research staff.  Collectively, our investigators have vast experience conducting phase II through phase IV clinical trials in a broad range of neurologic diseases affecting adults and children.


Adult Migraine

  • Phase 4 study evaluating outcomes for migraine patients in real world healthcare systems
  • Oral ubrogepant in the treatment of migraine when administered during migraine prodromal phase

Pediatric Migraine

  • Erenumab (Aimovig) for episodic and chronic migraine prophylaxis, 6-18 years of age
  • A multicenter, randomized, double blind, placebo controlled, parallel-group study comparing the efficacy, safety and tolerability of subcutaneous administration of fremanezumab versus placebo for the prophylactic treatment of chronic or episodic migraine in pediatric patients, 6-17 years of age
  • A randomized, double-blind, placebo-controlled study of lasmiditan for acute treatment of migraine

Multiple Sclerosis

  • Phase 3 multi-center, randomized study of evobrutinib in patients with relapsing multiple sclerosis
  • Phase 4 observational trial for Multiple Sclerosis patients taking cladribine
  • Phase 4 observational trial for Multiple Sclerosis patients taking siponimod
  • Phase 4 observational Study of Long-term Surveillance of ocrelizumab-treated patients with Multiple Sclerosis
  • Phase 4 study evaluating the processing speed of MS patients treated with ozanimod
  • Phase 4 single-arm, prospective, multicenter, open-label study to evaluate ofatumumab treatment effectiveness and patient-reported outcomes in patients with relapsing multiple sclerosis transitioning from dimethyl fumurate or fingolimod therapy to ofatumumab.

Neurogenic Orthostatic Hypotension

  • Phase 4 long-term outcome study of droxidopa (Northera) in patients with orthostatic hypotension
  • Phase 3 trial to assess the safety and efficacy of TD-9855 in neurogenic orthostatic hypotension

Trigeminal Neuralgia

  • Phase 3 study evaluating the efficacy and safety of vixotrigine in subjects with trigeminal neuralgia

Myasthenia Gravis

  • Phase 3 trial to assess the safety and efficacy of ravulizumab in patients with Myasthenia Gravis


Please contact one of our research coordinators for additional information:
Jodi Ventimiglia 719-389-1126


Research Staff